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Size options

PILOT D60 MAGNETIC MIXER ASSEMBLIES

The go-to solution for pilot-scale applications (till 1000 L working volumes). The D60 series magnetic mixers throughout the years gained increased interest for their unique ability of providing high mass transfer rates in pilot-scale vessels, which raises them above other alternatives. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way, so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment.
Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.

PILOT/INDUSTRIAL D100 MAGNETIC MIXER ASSEMBLIES

An ideal solution for transitional applications (from pilot to industrial scale). The D101 series mixers have proved themselves suitable even for 20 m3 working volume tanks. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way, so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment. Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.

Material in contact with product

316L Stainless steel, SiC, ZrO2 ,Silicone or Vitton

Rotor type

D100 series magnetic rotors

Rated torque (per each rotor), N.m

160-390

Containment housing outer diameter, mm

101

Agitation rate range,

(depends on application)

Working position

Vertical

Installation position

Bottom

Maximal working temperature

80℃

Maximal temperature during sterilization

135℃

Maximal time during sterilization

60 minutes

D101 magnet mixer assembly
D156 magnetic mixer

INDUSTRIAL D156 MAGNETIC MIXER ASSEMBLIES

The ultimate powerhouse of magnetic mixing. The D156 series magnetic mixers are the most powerful solution for industrial-scale applications. With a whopping rated torque of 1100 N.m per individual rotor, the D156 series mixers can be applied in vessels till 50 m3 working volumes. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer, the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment. Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.

Sizing guide

D20 for Vessel 5-20

D38 for Vessel 30-200L

D60 for Vessel 200-1000L

D101 for Vessel 1000 - 20000L

D156 for Vessel >20000L

Top installation animation

Bottom installation animation

edf-5.5-db-mo.jpg

EDF 5.5 Liter

Bioreactors

edf-5.5-db-mo.jpg

Double bottom vessel  

EDF-5.5-DB-MO 

Microbiology  

MAGNETIC MIXERS

Novel magnetic drive improves the sterility and ensures intensive mixing  conditions

SIMENS SIMATIC S7-1500

based control and 15” operator panel create  high standard of process supervision and more

USER-FRIENDLY, EFFICIENT

TWO VESSEL OPTIONS

CLEANABLE, STERILE LID

Advanced Operator Panel: Marking, Actions, Recipe Management, and Enhanced Functionality

1.  Glass vessel with metallic bottom.

.2. Classical double jacketed glass vessel.

No welded components in the lid create ideal cleaning and sterility conditions

EDF 5.5 Liter Bioreactors for:

Application

Microbiology

Jacketed Glass vessel

Double bottom vessel

Cell cultures

Photosynthetic cultures

Photosynthetic

and microbiology cultures

Find more detailed information on all of our laboratory bioreactors

in our catalogue

Features and benefits
Novel magnetic drive improves the sterility and ensures intensive mixing  conditions

Siemens Simatic S7-1500 based control and 15” operator panel create  high standard of process supervision , ensures remote service of software, and hardware service from local Siemens representative

User friendly operator panel with many functional

possibilities such as

  • Marking of sampling and induction time and volume

  • Operator action journal

  • Creating, selecting, saving and editing of recipes.  

 

Two vessel options:

1.  Glass vessel with metallic bottom

2.  Classical double jacketed glass vessel

No welded components in the lid create ideal cleaning and sterility conditions

Convenient design with collapsible condenser to decrease the height of vessel during autoclaving

NEW! Overpressure automatic control allows to keep pressure in overlay for better mass transfer and sterility

NEW! Online measuring of oxygen mass transfer coefficient kLa gives the possibility for operative monitoring of process performance

Built-in inlet gas pressure reductors and quick connectors of thermostating/cooling water ensures easy preparation for fermentations

Wide fed-batch configuration options allow to achieve high biomass and product densities

Operator Panel Screenshots
Advanced Operator Panel: Marking, Actions, Recipe Management, and Enhanced Functionality
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Thanks for your interest!

EDF 5.5 Liter Bioreactors:

edf-5.5-db-mo.jpg

Microbiology

EDF-5.5-DB-MO

Double bottom vessel

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 4.5

LED Lighting   None

Vessel type   Metallic double bottom with bottom sterilizable sampler

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air, + O2 (option)

Flow range, L/min   0.5 - 10

Sparger   Ring sparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 1200

Mixer   2 Rushton turbines

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base
2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + О2 (option).
0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) х 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

Microbiology

EDF-5.5-JG-MO

Jacketed Glass vessel

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

edf-5.5-jg-mo2.jpg

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 5

LED Lighting   None

Vessel type   Jacketed glass vessel

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air, + O2 (option)

Flow range, L/min   0.5 - 10

Sparger   Ring sparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 1200

Mixer   2 Rushton turbines

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base
2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + О2 (option).
0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) х 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

edf-5.5-db-cc.jpg

Cell cultures

EDF-5.5-DB-CC

Double bottom vessel

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 5

LED Lighting   None

Vessel type   Metallic double bottom with bottom sterilizable sampler

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air/CO2, + O2, N2 (option) ; Air/CO2 in headspace

Flow range, L/min   0.1 - 2 (other - option)

Sparger   Microsparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 500

Mixer   2 pitched blade impellers

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc). Acid/ Base Base/CO2 ; 2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc). Control: mixing + air/ O2/ N2 / CO2 (option); 0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) х 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

Cell cultures

EDF-5.5-JG-CC

Jacketed Glass vessel

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

edf-5.5-jg-mo.jpg

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 5

LED Lighting   None

Vessel type   Jacketed glass vessel

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air/CO2, + O2, N2 (option);  Air/CO2 in headspace

Flow range, L/min   0.1 - 2 (other - option)

Sparger   Microsparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 500

Mixer   2 pitched blade impellers

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc). Acid/ Base Base/CO2 ; 2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc). Control: mixing + air/ O2/ N2 / CO2 (option); 0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) x 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

edf-5.5-db-pbr.jpg

Photosynthetic cultures

EDF-5.5-DB-PBR

Double bottom vessel

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 5

LED Lighting   Removeable LED Light. Intensity control range – 0 – 1500 μmol/m2/s. Screen surface – 1350 cm2.

Vessel type   Metallic double bottom with bottom sterilizable sampler

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air, + O2 (option)

Flow range, L/min   0.5 - 10

Sparger   Ring sparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 1200

Mixer   2 Rushton turbines (Interchangeable pitched blade option)

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base; 2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + O2 (option); 0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) х 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

Microbiology

EDF-5.5-DB-PBRMO

Metallic double bottom with bottom sterilizable sampler With LED panels

1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process  2. Double jacketed glass vessel The increased heating area provides more uniform heating

3. Photobioreactor vessel

The addition of programmable LED array allows for cultivation of photosynthetic microorganisms

edf-5.5-db-pbr.jpg

Vessel

Total volume (L)   6.2

Working volume (L)   2 – 5

LED Lighting   None

Vessel type   Jacketed glass vessel

Diameter/ Height (mm)   150/350

Aeration

Control   Rotameter, TMFC (option)

Gas supply   Air, + O2 (option)

Flow range, L/min   0.5 - 10

Sparger   Ring sparger

Filters   D51 mm 0.2 μm PTFE

Exhaust gas condensor   Cooling from water – line or chiller

Mixing

Drive  Top magnetically coupled aseptic mixer

Rotation speed range (rpm)  40 - 1200

Mixer   2 Rushton turbines

Control

Controller   Siemens Simatic S7 - 1500

Operator panel   Touch screen BeeTronics, 15TS7 15’’ LED

Temperature   Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)

pH   Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base; 2 - 12 +/- 0,01pH units

pO2   Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + O2 (option); 0 - 150 % +/- 1%

Foam / Level   Conductivity sensor

Feeding   0.2 - 40 ml/min according adjusted profile

Peristaltic pumps   4 built – in stepper precision peristaltic pumps. External pump (option)

Dimensions

Total (mm)   930 (W) х 800(H) х 600(D)

Autocalving

Required place (mm)   590 (H) x 270 (D)

DB-MO
JG-MO
DB-CC
JG-CC
DB-PBRMO
DB-PBR
Models
Features
END
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