Size options
PILOT D60 MAGNETIC MIXER ASSEMBLIES
The go-to solution for pilot-scale applications (till 1000 L working volumes). The D60 series magnetic mixers throughout the years gained increased interest for their unique ability of providing high mass transfer rates in pilot-scale vessels, which raises them above other alternatives. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way, so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment.
Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.
PILOT/INDUSTRIAL D100 MAGNETIC MIXER ASSEMBLIES
An ideal solution for transitional applications (from pilot to industrial scale). The D101 series mixers have proved themselves suitable even for 20 m3 working volume tanks. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way, so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment. Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.
Material in contact with product
316L Stainless steel, SiC, ZrO2 ,Silicone or Vitton
Rotor type
D100 series magnetic rotors
Rated torque (per each rotor), N.m
160-390
Containment housing outer diameter, mm
101
Agitation rate range,
(depends on application)
Working position
Vertical
Installation position
Bottom
Maximal working temperature
80℃
Maximal temperature during sterilization
135℃
Maximal time during sterilization
60 minutes
INDUSTRIAL D156 MAGNETIC MIXER ASSEMBLIES
The ultimate powerhouse of magnetic mixing. The D156 series magnetic mixers are the most powerful solution for industrial-scale applications. With a whopping rated torque of 1100 N.m per individual rotor, the D156 series mixers can be applied in vessels till 50 m3 working volumes. In the proposed design, a gap between the outer rotors and the hermetic containment housing is maintained in order to avoid grinding between rotating and static elements. Simultaneously, two concentric lines of suction slots were machined into the body of the outer rotor. The upper layer slots guide the liquid in such a way so that the movement on the boundary layer during rotation would be directed towards the gap between the containment housing and outer rotor. In the vicinity of the lower suction slot layer, the flow direction is opposite that of the upper layer, so that liquid would move from the air gap to the outside environment. Such design aspects, considering the suction slots, were envisioned, in order to avoid flow stagnation in the air gap between the outer rotor and the containment housing, which is crucial during both microorganism cultivation/fermentation processes and CIP procedures.
Sizing guide
D20 for Vessel 5-20
D38 for Vessel 30-200L
D60 for Vessel 200-1000L
D101 for Vessel 1000 - 20000L
D156 for Vessel >20000L
Top installation animation
Bottom installation animation
MAGNETIC MIXERS
Novel magnetic drive improves the sterility and ensures intensive mixing conditions
SIMENS SIMATIC S7-1500
based control and 15” operator panel create high standard of process supervision and more
USER-FRIENDLY, EFFICIENT
TWO VESSEL OPTIONS
CLEANABLE, STERILE LID
Advanced Operator Panel: Marking, Actions, Recipe Management, and Enhanced Functionality
1. Glass vessel with metallic bottom.
.2. Classical double jacketed glass vessel.
No welded components in the lid create ideal cleaning and sterility conditions
EDF 5.5 Liter Bioreactors for:
Application
Microbiology
Jacketed Glass vessel
Double bottom vessel
Cell cultures
Photosynthetic cultures
Photosynthetic
and microbiology cultures
Find more detailed information on all of our laboratory bioreactors
in our catalogue
Features and benefits
Novel magnetic drive improves the sterility and ensures intensive mixing conditions
Siemens Simatic S7-1500 based control and 15” operator panel create high standard of process supervision , ensures remote service of software, and hardware service from local Siemens representative
User friendly operator panel with many functional
possibilities such as
-
Marking of sampling and induction time and volume
-
Operator action journal
-
Creating, selecting, saving and editing of recipes.
Two vessel options:
1. Glass vessel with metallic bottom
2. Classical double jacketed glass vessel
No welded components in the lid create ideal cleaning and sterility conditions
Convenient design with collapsible condenser to decrease the height of vessel during autoclaving
NEW! Overpressure automatic control allows to keep pressure in overlay for better mass transfer and sterility
NEW! Online measuring of oxygen mass transfer coefficient kLa gives the possibility for operative monitoring of process performance
Built-in inlet gas pressure reductors and quick connectors of thermostating/cooling water ensures easy preparation for fermentations
Wide fed-batch configuration options allow to achieve high biomass and product densities
Operator Panel Screenshots
Advanced Operator Panel: Marking, Actions, Recipe Management, and Enhanced Functionality
EDF 5.5 Liter Bioreactors:
Microbiology
EDF-5.5-DB-MO
Double bottom vessel
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 4.5
LED Lighting None
Vessel type Metallic double bottom with bottom sterilizable sampler
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air, + O2 (option)
Flow range, L/min 0.5 - 10
Sparger Ring sparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 1200
Mixer 2 Rushton turbines
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base
2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + О2 (option).
0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) х 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)
Microbiology
EDF-5.5-JG-MO
Jacketed Glass vessel
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 5
LED Lighting None
Vessel type Jacketed glass vessel
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air, + O2 (option)
Flow range, L/min 0.5 - 10
Sparger Ring sparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 1200
Mixer 2 Rushton turbines
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base
2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + О2 (option).
0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) х 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)
Cell cultures
EDF-5.5-DB-CC
Double bottom vessel
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 5
LED Lighting None
Vessel type Metallic double bottom with bottom sterilizable sampler
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air/CO2, + O2, N2 (option) ; Air/CO2 in headspace
Flow range, L/min 0.1 - 2 (other - option)
Sparger Microsparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 500
Mixer 2 pitched blade impellers
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc). Acid/ Base Base/CO2 ; 2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc). Control: mixing + air/ O2/ N2 / CO2 (option); 0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) х 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)
Cell cultures
EDF-5.5-JG-CC
Jacketed Glass vessel
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 5
LED Lighting None
Vessel type Jacketed glass vessel
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air/CO2, + O2, N2 (option); Air/CO2 in headspace
Flow range, L/min 0.1 - 2 (other - option)
Sparger Microsparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 500
Mixer 2 pitched blade impellers
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc). Acid/ Base Base/CO2 ; 2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc). Control: mixing + air/ O2/ N2 / CO2 (option); 0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) x 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)
Photosynthetic cultures
EDF-5.5-DB-PBR
Double bottom vessel
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 5
LED Lighting Removeable LED Light. Intensity control range – 0 – 1500 μmol/m2/s. Screen surface – 1350 cm2.
Vessel type Metallic double bottom with bottom sterilizable sampler
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air, + O2 (option)
Flow range, L/min 0.5 - 10
Sparger Ring sparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 1200
Mixer 2 Rushton turbines (Interchangeable pitched blade option)
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base; 2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + O2 (option); 0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) х 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)
Microbiology
EDF-5.5-DB-PBRMO
Metallic double bottom with bottom sterilizable sampler With LED panels
1. Glass vessel with metallic bottom The autoclavable sampling device at the bottom facilitates operational activities during the fermentation process 2. Double jacketed glass vessel The increased heating area provides more uniform heating
3. Photobioreactor vessel
The addition of programmable LED array allows for cultivation of photosynthetic microorganisms
Vessel
Total volume (L) 6.2
Working volume (L) 2 – 5
LED Lighting None
Vessel type Jacketed glass vessel
Diameter/ Height (mm) 150/350
Aeration
Control Rotameter, TMFC (option)
Gas supply Air, + O2 (option)
Flow range, L/min 0.5 - 10
Sparger Ring sparger
Filters D51 mm 0.2 μm PTFE
Exhaust gas condensor Cooling from water – line or chiller
Mixing
Drive Top magnetically coupled aseptic mixer
Rotation speed range (rpm) 40 - 1200
Mixer 2 Rushton turbines
Control
Controller Siemens Simatic S7 - 1500
Operator panel Touch screen BeeTronics, 15TS7 15’’ LED
Temperature Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from + 5 °C via coolant to 60 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature regulation within the prescribed range is ± 0,2 °C (with option up to 90°C)
pH Hamilton or Mettler Toledo sensors (different options, including Arc).
Acid/ Base; 2 - 12 +/- 0,01pH units
pO2 Hamilton or Mettler Toledo sensors (different options, including Arc).
Control: mixing + O2 (option); 0 - 150 % +/- 1%
Foam / Level Conductivity sensor
Feeding 0.2 - 40 ml/min according adjusted profile
Peristaltic pumps 4 built – in stepper precision peristaltic pumps. External pump (option)
Dimensions
Total (mm) 930 (W) х 800(H) х 600(D)
Autocalving
Required place (mm) 590 (H) x 270 (D)